An easy example would be to say "aaah" as if the doctor has just stuck that wooden thing down your throat. Now put the tube in your mouth and shape your mouth as if you are going to say "aaaah" but don’t! Let the instrument supply the sound. If you are playing guitar, play a note on the low E string as you will find it easier to sound out your first sound using a low note. Remember you still have your mouth shaped for the sound "aaaah". Now, as you play the note the guitar will be singing/saying "aaaah". Change the shape of your mouth and hear just how different the sound is with very little movement at all.
Some consonants are more difficult than others and just like any other instrument, 'The Framptone' needs you to practice and experiment. In reality, it took me quite a while before I was able to say "Hello Santa Monica!". Singing along while playing, 'The Framptone' is another effect I use sometimes. This effect is used specifically at the very end of, 'The Framptone' solo on the live version of 'Do You Feel Like We Do?'
Enjoy and many thanks - Peter Frampton